Full Paper
Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T1 measurements†
Greg O. Cron,
Giles Santyr,
Frederick Kelcz,
Corresponding Author
Greg O. Cron
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.
Carleton University, Department of Physics, Herzberg Laboratories, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6.===Search for more papers by this authorGiles Santyr
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.
Department of Physics, Carleton University, Ottawa, Ontario, Canada.
Search for more papers by this authorFrederick Kelcz
Department of Radiology, University of Wisconsin, Madison, Wisconsin.
Search for more papers by this authorGreg O. Cron,
Giles Santyr,
Frederick Kelcz,
Corresponding Author
Greg O. Cron
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.
Carleton University, Department of Physics, Herzberg Laboratories, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6.===Search for more papers by this authorGiles Santyr
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.
Department of Physics, Carleton University, Ottawa, Ontario, Canada.
Search for more papers by this authorFrederick Kelcz
Department of Radiology, University of Wisconsin, Madison, Wisconsin.
Search for more papers by this authorFirst published: 28 September 1999
Citations: 25
†
Presented in part at the Fifth Meeting of the ISMRM, Vancouver, 1997.
Abstract
A method is presented that converts dynamic T1-weighted spoiled gradient-recalled echo (SGRE) image intensities into estimates of T1 without the errors associated with imperfections in the slice profile and transmitter coil magnetic field (B1). The method involves T1 measurements performed before and after a series of dynamic SGRE images. These measurements serve to calibrate and correct the SGRE signal strength equation used to estimate T1. Simulations and phantom experiments were performed to test the method for slice-selective (two-dimensional) and slab-selective (three-dimensional) imaging, as well as for imaging performed with optimized and un-optimized B1. For nearly all test conditions, T1 was estimated accurately (within 10%) over a range of T1 values expected in vivo (∼1200 → 300 msec). This method should be useful for quantifying dynamic SGRE imaging for many different applications including breast MR imaging. Magn Reson Med 42:746–753, 1999. © 1999 Wiley-Liss, Inc.
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