Communication
Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones
First published: 30 November 1999
Citations: 180
Abstract
High enantioselectivity (up to 98 % ee) has been achieved for the conjugate addition of diethylzinc to acyclic enones utilizing CuI complexes of the novel chiral P,N ligands 1. The high enantioselectivities are best achieved using [Cu(OTf)]2⋅C6H6 as the copper catalyst precursor in nonpolar solvents such as toluene or Cl(CH2)2Cl. R=H, CH3; Tf=F3CSO2.
