Angewandte Chemie International Edition
Volume 38, Issue 1-2 pp. 126-128
Communication

Synthesis of Mono- and Di(oxopyri)porphyrins: A New Approach through Ring Enlargement with Diazomethane

Andrei N. Kozyrev, 

Andrei N. Kozyrev

Chemistry Section, Photodynamic Therapy Center, Department of Radiation Biology, Roswell Park Cancer Institute, Buffalo, NY 14263 (USA), Fax: (+1) 716-845-8920

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James L. Alderfer, 

James L. Alderfer

Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263 (USA)

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Thomas J. Dougherty, 

Thomas J. Dougherty

Chemistry Section, Photodynamic Therapy Center, Department of Radiation Biology, Roswell Park Cancer Institute, Buffalo, NY 14263 (USA), Fax: (+1) 716-845-8920

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Ravindra K. Pandey, 

Ravindra K. Pandey

Chemistry Section, Photodynamic Therapy Center, Department of Radiation Biology, Roswell Park Cancer Institute, Buffalo, NY 14263 (USA), Fax: (+1) 716-845-8920

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First published: 04 February 2004
https://doi.org/10.1002/(SICI)1521-3773(19990115)38:1/2<126::AID-ANIE126>3.0.CO;2-U
Citations: 29

Abstract

A novel approach for porphyrin modification is provided by ring-enlargement reactions. Treatment of dioxochlorins (see scheme) and tetraoxobacteriochlorins with diazomethane results in formation of the corresponding mono- and di(oxopyri)porphyrins.

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