Volume 12, Issue 8 pp. 557-561

Original Paper

Prevention of acetaminophen-induced hepatotoxicity by ternatin, a bioflavonoid from Egletes viscosa less

M. F. Souza,

M. F. Souza

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, C. P. 3157, 60 430 - 270 Fortaleza, Ce, Brazil

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V. S. N. Rao,

Corresponding Author

V. S. N. Rao

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, C. P. 3157, 60 430 - 270 Fortaleza, Ce, Brazil

Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Cel Nunes de Melo, 1127, Porangabussu, C.P.3157, 60430-270 Fortaleza, Ceará, Brazil.Search for more papers by this author

E. R. Silveira,

E. R. Silveira

Departamento de Quimica Orgânica, e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ce, Brazil

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M. F. Souza,

M. F. Souza

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, C. P. 3157, 60 430 - 270 Fortaleza, Ce, Brazil

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V. S. N. Rao,

Corresponding Author

V. S. N. Rao

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, C. P. 3157, 60 430 - 270 Fortaleza, Ce, Brazil

E. R. Silveira,

E. R. Silveira

Departamento de Quimica Orgânica, e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ce, Brazil

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First published: 21 December 1998

https://doi.org/10.1002/(SICI)1099-1573(199812)12:8<557::AID-PTR355>3.0.CO;2-W

Citations: 4

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Abstract

The hepatoprotective effect of ternatin, a tetramethoxyflavone from Egletes viscosa L. was investigated in mice against acetaminophen-induced hepatic damage and lethality. Hepatotoxicity was assessed by quantifying serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactic dehydrogenase (LD) and malondialdehyde (MDA) concentration in liver homogenates as well as by histopathological examination of liver tissue. Acetaminophen (300 mg/kg) produced liver damage in mice as manifested by a 29-, 23- and 7-fold rise in serum levels of ALT, AST and LD, respectively, compared with controls. Ternatin (25 and 50 mg/kg) was able to prevent significantly (p < 0.05) acetaminophen-induced acute increase in serum enzymes. In addition, the severity of histological alterations induced by acetaminophen as evidenced by centrilobular necrosis and cellular infiltration were greatly diminished in animals that received ternatin. The data suggest a hepatoprotective activity of ternatin in mice against toxicity induced by acetaminophen. Copyright © 1998 John Wiley & Sons, Ltd.

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Volume12, Issue8

December 1998

Pages 557-561

Prevention of acetaminophen-induced hepatotoxicity by ternatin, a bioflavonoid from Egletes viscosa less

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Prevention of acetaminophen-induced hepatotoxicity by ternatin, a bioflavonoid from Egletes viscosa less

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