Volume 11, Issue 4 pp. 317-319
Short Communication

Analgesic and central depressor effects of the dichloromethanol extract from Schinus molle L.

M. D. Barrachina

M. D. Barrachina

Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, Spain

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R. Bello

Corresponding Author

R. Bello

Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, Spain

Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, SpainSearch for more papers by this author
M. A. Martínez-Cuesta

M. A. Martínez-Cuesta

Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, Spain

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E. Primo-Yúfera

E. Primo-Yúfera

Instituto de Technologías Químacas, Universidad Politénica de Valencia, CSIC, Valencia, Spain

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J. Esplunges

J. Esplunges

Departamento de Farmacología, Facultad de Medicina y Odontología, Universidad de Valencia, Spain

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Abstract

The analgesic and central depressor effects of the dichloromethanol extract of Schinus molle L. were analysed in in vivo models. This extract showed low acute toxicity, CNS depressor activity and analgesic effect. Following further fractionation, the hexane/dichloromethane (75/25) fraction showed the most interesting results. Thus, this fraction caused a total inhibition of motor activity and significantly reduced the threshold of pain to chemical stimulus. © 1997 John Wiley & Sons, Ltd.

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