Volume 10, Issue 7 pp. 622-624
Research Article

Extract from Sickingia williamsii Reduces Morphine Withdrawal in vitro

A. Capasso

Corresponding Author

A. Capasso

School of Pharmacy, University of Salerno, Piazza Vittorio Emanuele 9 (84084), Penta di Fisciano, Salerno, Italy

School of Pharmacy, University of Salerno, Piazza Vittorio Emanuele 9 (84084), Penta di Fisciano, Salerno, ItalySearch for more papers by this author
R. Aquino

R. Aquino

School of Pharmacy, University of Salerno, Piazza Vittorio Emanuele 9 (84084), Penta di Fisciano, Salerno, Italy

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F. De Simone

F. De Simone

School of Pharmacy, University of Salerno, Piazza Vittorio Emanuele 9 (84084), Penta di Fisciano, Salerno, Italy

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L. Sorrentino

L. Sorrentino

Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49 (80131), Naples, Italy

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Abstract

The present study examined the effect of an extract from Sickingia williamsii Standl. (Rubiaceae) on morphine withdrawal in vitro. The extract of S. williamsii (50–100–250 μg\mL organ bath) significantly and in a concentration dependent manner reduced the morphine withdrawal. The results of the present study suggest that this extract may be a potential antiaddictive agent.

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