Research Article
MODELLING HUMAN LEUKEMIA AND LYMPHOMA IN SEVERE COMBINED IMMUNODEFICIENT (SCID) MICE: PRACTICAL APPLICATIONS
DAVID J. FLAVELL,
DAVID J. FLAVELL
The Simon Flavell Leukaemia Research Laboratory, University Department of Pathology, Southampton General Hospital, Southampton, Hampshire SO16 6YD, U.K.
Search for more papers by this authorDAVID J. FLAVELL,
DAVID J. FLAVELL
The Simon Flavell Leukaemia Research Laboratory, University Department of Pathology, Southampton General Hospital, Southampton, Hampshire SO16 6YD, U.K.
Search for more papers by this authorFirst published: June 1996
Citations: 7
1099-1069(199606)14:2<67::aid-hon567>3.0.co;2-u.fp.png)
References
- 1 Bosma, G. C, Custer, R. P., Bosma, M. J., A severe combined immunodeficiency mutation in the mouse. Nature 1983, 301, 527–530.
- 2 Dorshkind, K., Pollack, S. B., Bosma, M. J., Phillips, R. A., Natural killer cells are present in mice with severe combined immunodeficiency. J. Immunol. 1985, 134, 3798–3801.
- 3 Kotloff, D. B., Bosma, M. J., Ruetsch, N. R., SCID mouse pre-B cells with intracellular/J chains: analysis of recombinase activity and IgH gene rearrangements. Int. Immunol. 1993, 5, 383–391.
- 4 Kamel-Reid, S., Letarte, M., Sirard, C, Doedens, M., Grunberger, T., Fulop, G., Freedman, M. H., Phillips, R. A., Dick, J. E., A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science 1989, 246, 1597–1600.
- 5 Cesano, A., O'Connor, R., Lange, B., Finan, J., Rovera, G., Santoli, D., Homing and progression patterns of childhood acute lymphoblastic leukaemias in severe combined immunodeficient mice. flW 1991, 77, 2463–2474.
- 6 Kawata, A., Yoshida, M., Okazaki, M., Yokota, S., Barcos, M., Seon, B. K., Establishment of new SCID and nude moouse models of human B leukemia/lymphoma and effective therapy of the tumours with immunotoxin and monoclonal antibody: Marked difference between the SCID and nude mouse models in the antitumour efficacy of monoclonal antibody. Cancer Res. 1994, 54, 2688–2694.
- 7 Ishihara, S., Tachibana, N., Okayama, A., Murai, K., Tsuda, K., Mueller, N., Successful graft of HTLC-1 -transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody. Jpn. J. Cancer Res. 1992, 83, 320–323.
- 8 Isshi, E., Greaves, A., Grunberger, T., Freedman, M. H., Letarte, M., Tumour formation by a human pre-B leukemia cell line in scid mice is enhanced by matrigel and is associated with induction of CD10 expression. Leukemia 1995, 9, 175–184.
- 9 Kamel-Reid, S., Dick, J. E., Greaves, A., Murdoch, B., Doedens, M., Grunberger, T., Thorner, P., Freedman, M. H., Phillips, R. A., Letarte, M., Differential kinetics of engraftment and induction of CD10 on human pre-B-cell leukemia cell lines in immune deficient scid mice. Leukemia 1992, 6, 8–17.
- 10 Morland, B. J., Barley, J., Boehm, D., Flavell, S. U., Ghaleb, N., Kohler, J. A., Okayama, K., Wilkins, B., Flavell, D. J., Effectiveness of HB2(anti-CD7)-saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice. Brit. J. Cancer 1994, 69, 279–285.
- 11 Cattan, A. R., Douglas, E. The C.B., 17 SCID mouse as a model for human disseminated leukaemia and myeloma in vivo. Leuk. Res. 1994, 18, 513–522.
- 12 Uittenbogaart, C. H., Anisman, D. J., Tary-Lehmann, M., Vollger, L. W., Brett, T. M., Dongen, J. J. M. V., Saxon, A. The SCID mouse environment causes immunophenotypic changes in human immataure T-cell lines. Int. J. Cancer 1994, 56, 546–551.
- 13 Cesano, A., O'Connor, R., Nowell, P. C, Lange, B., Clark, S. C, Santoli, D., Establishment of a karyotypically normal cytotoxic leukemic T-cell line from a T-ALL sample engrafted in SCID mice. Blood 1993, 81, 2714–2722.
- 14 Kondo, A., Imada, K., Hattori, T., Yamabe, H., Tanaka, T., Miyasaka, M., Okuma, M., Uchiyama, T. A, model of in vivo cell proliferation of adult T-cell leukemia. Blood 1993, 82, 2501–2509.
- 15 Uckun, F. M., Downing, J. R., Chelstrom, L. M., Gunther, R., Ryan, M., Simon, J., Caroll, A. J., Tuel-Ahlgren, L., Crist, W. M., Human t(4;ll)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood 1994, 84, 859–865.
- 16 Uckun, F. M., Downing, J. R., Gunther, R., Chelstrom, L. M., Finnegan, D., Land, V. J., Borowitz, M. J., Caroll, A. J., Crist, W. M., Human t(l;19)(q23;pl3) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood 1993, 81, 3052–3062.
- 17 Uckun, F. M., Sather, H., Reaman, G., Sinister, J., Land, V., Trigg, M., Gunther, R., Chelstrom, L., Bleyer, A., Gaynon, P., Crist, W., Leukemic cell growth in SCID mice as a predictor of relapse in high risk B-lineage acute lymphoblastic leukaemia. Blood 1995, 85, 873–878.
- 18 Kamel-Reid, S., Letarte, M., Doedens, M., Greaves, A., Murdoch, B., Grunberger, T., Lapidot, T., Thorner, P., Freedman, M. H., Phillips, R. A., Dick, J. E., Bone marrow from children in relapse with pre-B acute lymphoblastic leukaemia proliferates and disseminates rapidly in SCID mice. Blood 1991, 78, 2973–2981.
- 19 Beran, M., Pisa, P., Kantarjian, H., Porwit, A., Bjorkholm, M., Growth of sensitive and drug-resistant human myeloid leukemia cells in SCID mice. Hematol. Pathol. 1994, 8, 135–154.
- 20 Beran, M., Pisa, P., O'Brien, S., Kurzrock, R., Siciliano, M., Cork, A., Andersson, B. S., Kohli, V., Kantarjian, H., Biological properties and growth in SCID mice of a new myelogenous leukemia cell line (KBM-5) derived from chronic myelogenous leukemia cells in the blastic phase. Cancer Res. 1993, 53, 3603–3610.
- 21 Cesano, A., Hoxie, J. A., Lange, B., Nowell, P. C, Bishop, J., Santoli, D., The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias. Oncogene 1992, 7, 827–836.
- 22 Sawyers, C. L., Gishizky, M. L., Quan, S., Golde, D. W., Witte, W. N., Propagation of human blastic myeloid leukemias in the SCID mouse. Blood 1992, 79, 2089–2098.
- 23 Shpitz, B., Fernandes, B. J., Mullen, J. B. M., Roder, J. C, Gallinger, S., Improved engraftment of human tumours in SCID mice pretreated with radiation and anti-asialo GM1. Anticancer Res. 1994. 14, 1927–1934.
- 24 Chelstrom, L. M., Gunther, R., Simon, J., Raimondi, S. C, Krance, R., Crist, W. M., Uckun, F. M., Childhood acute myeloid leukemia in mice with severe combined immunodeficiency. Blood 1994, 84, 20–26.
- 25 Namikawa, R., Ueda, R., Kyoizumi, S., Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice. Blood 1993, 82, 2526–2536.
- 26 Lapidot, T., Pflumio, F., Doedens, M., Murdoch, B., Willliams, D. E., Dick, J. E., Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 1992, 255, 1137–1141.
- 27 Tsukamoto, A. S., Reading, C, Carella, A., Frassoni, F., Gorin, C, LaPorte, J., Negrin, R., Blume, K., Cunningham, I., Deisseroth, A., Tricot, G., Barlogie, B., Tong, J., Murray, L., Berg, D. V. D., Hoffman, R., Biological characterization of stem cell present in mobilized peripheal blood of CML patients. Bone Marrow Transplant. 1994, 14, S25–S32.
- 28 Wang, J. C. Y., Lapidot, T., Cashman, J. D., Sirad, C, Doedens, M., Laraya, P., Addy, L., Minden, M., Keating, A., Eaves, A. C, Eaves, C. J., Dick, J. E., Engraftment of primitive normal and leukemic hematopoetic cells from chronic phase CML patients in immunodeficient mice. Blood 1995, 86, 601a.
- 29 Prochazka, M., Gaskins, H. R., Shultz, L. D., Leiter, E. H., The non-obese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 3290–3294.
- 30 Kobayashi, R., Picchio, G., Kirven, M., Meisenholder, G., Baird, S., Carson, D. A., Mosier, D. E., Kipps, T. J., Transfer of human chronic lymphocytic leukaemia to mice with severe combined immune deficiency. Leuk. Res. 1992, 16, 1013–1023.
- 31 Kawata, A., Han, T., Dadey, B., Weier, H.-U. G., Okazaki, M., Yokota, S., Fukiage, T., Xiao, H., Block, A. W., Barcos, M., Henderson, E., Yoshida, M., Seon, B. K., Establishment and characterization of the tumours of chronic lymphocytic leukemia cell line in nude and SCID mice. Leuk. Res. 1993, 17, 883–894.
- 32 Zhu, Z., Ghose, T., Hoskin, D., Lee, C. L. Y., Fernandex, L. A., Rowden, G., Lee, S. H. S., Inhibition of human B-cell chronic lymphocytic leukemia by a monoclonal antibody in xenograft models. Int. J. Cancer 1994, 56, 439–445.
- 33 Chang, H., Leeder, S., Cook, V. A., Patterson, B., Dosch, M., Minden, M. D., Messner, H. A., Growth of human lymphoma cells in SCID mice. Leuk. Lymph. 1992, 8, 129–136.
- 34 Ghetie, M.-A., Tucker, K., Richardson, J., Uhr, J. W., Vitetta, E. S., The antitumour activity of an anti-CD22 immunotoxin in SCID mice with dissminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin. Blood 1992, 80, 2351–2320.
- 35 Flavell, D. J., Boehm, D. A., Emery, L., Noss, A., Ramsay, A., Flavell, S. U., Therapy of human B-cell lymphoma bearing SCID mice is more efective with anti-CD 19 and anti-CD38-saporin immunotoxins used in combination than with either immunotoxin used alone. Int. J. Cancer 1995, 62, 337–344.
- 36 Wasik, M. A., Sioutos, N., Tuttle, M., Butmarc, J. R., Kaplan, W. D., Kadin, M. E., Constitutive secretion of soluble interleukin-2 receptor by human T-cell lymphoma xenografted into SCID mice. Correlation of tumour volume with concentraton of tumour-derived soluble interleukin-2 receptor in body fluids of the host mice. Amer. J. Pathol. 1994, 144, 1089–1097.
- 37
Ttoh, T.,
Shiota, M.,
Takanashi, M.,
Hojo, I.,
Satoh, H.,
Matsuzawa, A.,
Moriyama, T.,
Watanabe, T.,
Hirai, K.,
Mori, S.,
Engraftment of human non-Hodgkin lymphomas in mice with severe combined immunodeficiency.
Cancer
1993,
72,
2686–2694.
10.1002/1097-0142(19931101)72:9<2686::AID-CNCR2820720927>3.0.CO;2-T PubMed Web of Science® Google Scholar
- 38 Charley, M. R., Tharp, M, Locker, J., Deng, J. S., Golsen, J. B., Mauro, T., McCoy, P., Abell, E., Jegasothy, B., Establishment of a human cutaneous T-cell lymphoma in C.B-17 SCID mice. J. Invest. Dermatol. 1990, 94, 381–384.
- 39 Feuer, G. J. A., Zack, Jr, W. J. H., Valderama, R., Rosenblatt, J. D., Wachsman, W., Baird, S. M., Chen, I. S. Y., Establishment of human T-cell leukemia virus type I T-cell lymphomas in severe combined immunodeficient mice. Blood 1993, 82, 722–731.
- 40 Feuer, G., Stewart, S. A., Baird, S. M., Lee, F., Feuer, R., Chen, I. S. Y., Potential role of natural killer cells in controlling tumorigenesis by human T-cell leukemia viruses. J. Virol. 1995, 69, 1328–1333.
- 41 Waller, E. K., Kamel, O. W., Cleary, M. L., Maumdar, A. S., Schick, M. R., Lieberman, M., Weissman, I. L., Growth of primary T-cell non-Hodgkin's lymphomata in SCID-hu mice: requirement for a human lymphoid microenvironment. Blood 1991, 78, 2650–2665.
- 42 Waller, E. K., Ziemianska, M., Bangs, C. D., Cleary, M., Weissman, I., Kamel, O. W., Characterization of posttransplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics and heterotransplantation in severe combined immunodeficient mice. Blood 1993, 82, 247–261.
- 43 Amadori, A., Veronese, M. L., Mazza, M. R., Zamarchi, P., Mion, M., Dandrea, E., Menin, C, Mistro, A. D., Leszl, A., Calderazzo, F., Panozzo, M., ChiecoBianchi, L., Lymphoma induction by human B cells in scid mice. Leukemia 1992, 6, 23s–25s.
- 44 Boyle, T. J., Coles, R. E., Kizilbash, A. M., Lyerly, H. K., Effects of cyclosporine on human B-cell lymphoma development in vivo. Surg. Oncol. 1992, 1, 79–86.
- 45 Mosier, D. E., Picchio, G. R., Baird, S. M., Kobayashi, R., Kipps, T. J., Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes. Cancer Res. 1992, 52, 5552s–5553s.
- 46 Nadal, D., Albini, B., Schlapfer, E., Bernstein, J. M., Ogra, P. L., Role of Epstein-Barr virus and interleukin 6 in the development of lymphomas of human origin in SCID mice engrafted with human tonsillar mononuclear cells. J. Gen. Virol. 1992, 73, 113–121.
- 47 Picchio, G. R., Kobayashi, R., Kirven, M., Baird, S. M., Kipps, T. J., Mosier, D. E., Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts. Cancer Res. 1992, 52, 2468–2477.
- 48 Veronesi, M. L., Veronesi, A., Dandrea, E., Mistro, A. D., Indracollo, S., Mazza, M. R., Mion, M., Zamarchi, R., Menin, C, Panozzo, M., Amadori, A., ChiecoBianchi, K., Lymphoproliferative disease in human peripheral blood mononuclear cell-injected SCID mice. I. T lymphocyte requirement for B cell tumour generation. J. Exp. Med. 1992, 176, 1763–1767.
- 49 Boyle, T. J., Tamburini, M., Berend, K. R., Kizilbash, A. M., Borowitz, M. J., Lyerly, H. K., Human B-cell lymphoma in severe combined immunodeficient mice after active infection with Epstein-Barr virus. Surgery 1992, 112, 378–386.
- 50 Glaser, R., Theil, K. S., Bonneau, R. H., Sheridan, J. F., Vasquez, M., Allen, C. M., Virus-associated B-cell lymphoma in a SCID mouse. Int. J. Cancer 1993, 55, 281–287.
- 51 Fox, R. I., Pisa, P., Pisa, E. K., Kang, H. I., Lymphoproliferative disease in SCID mice reconstituted with human Sjogren's syndrome lymphocytes. J. Clin. Lab. Anal. 1993, 7, 46–56.
- 52 Veronesi, A., Coppola, V., Veronese, M. L., Menin, C, Bruni, L., Dandrea, E., Mion, M., Amadori, A., ChiecoBianchi, K., Lymphoproliferative disease in human peripheral-blood-mononuclear-cell-inject SCID mice. II. Role of host and donor factors in tumour generation. Int. J. Cancer 1994, 59, 676–683.
- 53 Veronese, M. L., Veronesi, A., Bruni, L., Coppola, V., Dandrea, E., Mistro, A. D., Mezzalira, S., Montagna, M., Ruffatto, G., Amadori, A., Properties of tumours arising in SCID mice injected with PBMC from EBV-positive donors. Leukaemia 1994, 8, S214–S217.
- 54 Rochford, R., Mosier, D. E., Differential Epstein-Barr virus gene expression in B-cell subsets recovered from lymphomas in SCID mice after transplantation of human peripheral blood lymphocytes. J. Virol. 1995, 69, 150–155.
- 55 Ahsmann, E. J. M., Tol, M. J. D. v., Oudeman-Gruber, J., Lokhorst, H., Uytdehaag, F. G. C. M., Schuurman, H. J., Bloem, A. C., The SCID mouse as a model for multiple myeloma. Brit. J. Haematol. 1995, 89, 319–327.
- 56 Feo-Zuppardi, F. J., Taylor, C. W., Iwato, K., Lopez, M. H. A., Grogan, T. M., Odeleye, A., Hersh, E. M., Salmon, S. E., Long term engraftment of fresh human myeloma cells in SOD mice. Blood 1992, 80, 2843–2850.
- 57 Huang, Y.-W., Richardson, J. A., Tong, A. W., Zhang, B.-Q., Stone, M. J., Vitetta, E. S., Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease. Cancer Res. 1993, 53, 1392–1396.
- 58 Tong, A. W., Huang, Y. W., Zhang, B. Q., Netto, G., Vitetta, E. S., Stone, M. J., Heterotransplantation of human multiple myeloma cell lines in severe combined immunodeficiency (SCID) mice. Anticancer Res. 1993, 13, 593–598.
- 59 Kapp, U., Dux, A., Schell-Frederick, E., Banik, N., Hummel, M., Mucke, S., Fonatsch, C, Bullerdiek, J., Gottstein, C, Engert, A., Diehl, V., Wolf, J., Disseminated growth of Hodgkin's-derived cell lines L540 and L450cy in immune-deficient SCID mice. Ann. Oncol. 1994, 5, S121–S126.
- 60 Kapp, U., Wolf, J., von-Kalle, C, Tawadros, S., Rottgen, A., Engert, A., Fonatsch, C., Stein, H., Diehl, V., Preliminary report: Growth of Hodgkin's lymphoma derived cells in immune compromised mice. Ann. Oncol. 1992, 3, S21–S23.
- 61 von-Kalle, C, Wolf, J., Becker, A., Sckaer, A., Munck, M., Engert, A., Kapp, U., Fonatsch, C, Komitowski, D., Feaux-de-Lacroix, W., Growth of Hodgkin cell lines in severely combined immunodeficient mice. Int. J. Cancer 1992, 52, 887–891.
- 62 Kapp, U., Wolf, J., Hummel, M., Pawlita, M., Kalle, C. v., Dallenbach, F., Schwonzen, M., Krueger, G. R. F., Muller-Lantzsch, N., Fonatsh, C, Stein, H., Diehl, V. Hodgkin's lymphoma-derived tissue serially transplanted into severe combined immunodeficient mice. Blood 1993, 82, 1247–1256.
- 63 Kroon, J. F. E. D., Kluin, P. M., KuinNelemans, H. C, Willemze, R., Falkenburg, J. H. F., Homing and antigenic characterization of a human Non-Hodgkin's lymphoma B cell line in severe combined immunodeficient (SCID) mice. Leukemia 1994, 8, 1385–1391.
- 64 Uckun, F. M., Manivel, C, Arthur, D., Chelstrom, L. M., Finnegan, N., Tuel-Ahlgren, L., Irvin, J. D., Myers, D. E., Gunther, R., In vivo efficacy of B43 (anti-CD 19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood 1992, 79, 2201–2214.
- 65 Flavell, D. J., Flavell, S. U., Boehm, D., Emery, L., Noss, A., Ling, N. R., Richardson, P. R., Hardie, D., Wright, D. H., Preclinical studies with the anti-CD 19-saporin immunotoxin BU12-SAPORIN for the treatment of human B-cell tumours. Brit. J. Cancer 1995, 72, 1373–1379.
- 66 Bashir, R., Coakman, H., Hochberg, F., Expression of LFA-l/ICAM-1 in CNS lymphomas: Possible mechanism for lymphoma homing into the brain. J. Neuro-Oncol. 1992, 12, 103–110.
- 67 Ishii, E., Greaves, A., Grunberger, T., Freedman, M. H., Letarte, M., The induction of CD10 on a pre-B-cell line occurs with progression of the disease in scid mice. Leukemia 1993, 7, 1592–1601.
- 68 Fishwild, D. M., Aberle, S., Bernhard, S. L., Kung, A. H. C., Efficacy of an anti-CD7-ricin A chain immunoconjugate in a novel murine model of human T-cell leukaemia. Cancer Res. 1992, 52, 3056–3062.
- 69 Uckun, F. M., Stewart, C. F., Reaman, G., Chelstrom, L. M., Jin, J., Chandan-Langlie, M., Waddick, K. G., White, J., Evans, W. E., In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukaemia cells. Blood 1995, 85, 2817–2828.
- 70 Bellamy, W. T., Odeleye, A., Finley, P., Huizenga, B., Dalton, W. S., Weinstein, R. S., Hersh, E. M., Grogan, T. M., An in vivo model of human multidrug-resistant multiple myeloma in SCID mice. Am. J. Pathol. 1993, 142, 691–697.
- 71 Lacerda, J. F., Goker, E., Kheradpour, A., Dennig, D., Elisseyeff, Y., Jagiello, C, O'Reilly, R. J., Bertino, J. R., Selective treatment of SCID mice bearing methotrexate-transport-resistant human acute lymphoblastic leukaemia tumours with trimetrexate and leucovorin protection. Blood 1995, 85, 2675–2679.
- 72 Liu, C, O'Connor, R., Derr, S., Shah, S. A., Blattler, W. A., Lambert, J. M., Overcoming drug resistance in vivo by anti-B4-blocked ricin immunotoxin against a human B-cell lymphoma. Proc. Am. Assoc. Cancer Res. 1994, 35, A2464.
- 73 Flavell, D. J., Boehm, D. A., Okayama, K., Kohler, J. A., Flavell, S. U., Therapy of human T-cell acute lymphoblastic leukaemia in severe combined immunodeficient mice with two different anti-CD7-saporin immunotoxins containing hindered or non-hindered disulphide cross linkers. Int. J. Cancer 1994, 58, 407–114.
- 74 Ghetie, A.-M., Picker, L. J., Richardson, J. A., Tucker, K., Uhr, J. W., Vitetta, E. S., Anti-CD19 inhibits the growth of human B cell tumour lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest. Blood 1994, 83, 1329–1336.
- 75 Ghetie, M. A., Richardson, J., Tucker, T., Jones, D., Uhr, J. W., Vitetta, E. S., Antitumor activity of Fab and IgG-anti-CD22 immunotoxins in dissminated human B-cell lymphoma grown in mie with severe combined immunodeficiency disease: effect on tumour cells in extranodal sites. Cancer Res. 1991, 51.
- 76 Funakoshi, S., Longo, D. L., Beckwith, M., Conley, D. K., Tsarfaty, G., Tsarfaty, I., Armitage, R., Fanslow, W. C, Spriggs, M. K., Murphy, W. J., Inhibition of human B-cell lymphoma growth by CD40 stimulation. Blood 1994, 83, 2787–2794.
- 77 Lucking-Famira, K. M., Daniel, P. T., Moller, P., Krammer, P., H. APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice. Leukemia 1994, 8, 1825–1833.
- 78 Suzuki, H., Yasukawa, K., Saito, T., Goitsuka, R., Hasegawa, A., Ohsugi, Y., Taga, T., Kishimoto, T., Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo. Eur. J. Immunol. 1992, 22, 1989–1993.
- 79 Huang, Y. W., Richardson, J. A., Vitetta, E. S., Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. Cancer Res. 1995, 55, 610–616.
- 80 Uckun, F. M., Chelstrom, L. M., Finnegan, D., Tuel-Ahlgren, L., Manivel, C, Irvin, J. D., Myers, D. E., Gunther, R., Effective immunotherapy of CALLA+C mu+human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD 19) pokeweed antiviral protein irnmunotoxin plus cyclophosphamide. Blood 1992, 79, 3116–3139.
- 81 Jansen, B., Uckun, F., Jaszcz, W. B., Kersey, J. H., Establishment of a human t(4;11) leukaemia in severe combined immunodeficient mice and successful treatment using anti-CD 19 (B43)-pokeweed antiviral protein irnmunotoxin. Cancer Res. 1992, 52, 406–412.
- 82 Pohl, C, Renner, C, Schwonzen, M., Schobert, I., Liebenberg, V., Jung, W., Wolf, J., Pfreundschuh, M., Diehl, V., CD30-specific AB1-AB2-AB3 internal image antibody network: Potentional use as anti-idiotype vaccine against Hodgkin's lymphoma. Int. J. Cancer 1993, 54, 418–425.
- 83 Cesano, A., Visonneau, S., Cioe, L., Clark, S. C, Rovera, G., Santoli, D., Reversal of acute myelogenous leukemia in humanized SCID mice using a novel adoptive transfer approach. J. Clin. Invest. 1994, 94, 1076–1084.
- 84 Malkovska, V., Cigel, F. K., Armstrong, N., Storer, B. E., Hong, R., Antilymphoma activity of human yd T-cells in mice with severe combined immune deficiency. Cancer Res. 1992, 52, 5610–5616.
- 85 Malkovska, V., Cigel, F., Storer, B. E., Human T-cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumour immunity. Clin. Exp. Immunol. 1994, 96, 158–165.
- 86 Lu, P. H., Negrin, R. S., A novel population of expanded human CD3 + CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J. Immunol. 1994, 153, 1687–1696.
- 87 Ratajczak, M. Z., Kant, J. A., Luger, S. M., Hijiya, N., Zhang, J., Zon, G., Gewirtz, A. M., In vivo treatment of human leukemia in a SCID mouse model with c-myb antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 11823–11827.
- 88 Skorski, T., Nieborowska-Skorska, M., Nicolaides, N., Szczylik, C, Iversen, P., Iozzo, R. V., Zon, G., Calabretta, B., Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide. Proc. Natl. Acad. Sci. U.S.A. 1994, 81, 4504–4508.
- 89 Cotter, F. E., Johnson, P., Hall, P., Pocock, C, Mahdi, N. A., Cowell, J. K., Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene 1994, 9, 3049–3055.
- 90 Cook, D. R., Maxwell, I. H., Glode, L. M., Maxwell, F., Stevens, J. O., Purner, M. B., Wagner, E., Curiel, D. T., Curiel, T. J., Gene therapy for B-cell lymphoma in a SCID mouse model using an immunoglobulin-regulated diphtheria toxin gene delivered by a novel adenovirus-polylysine conjugate. Cancer Biother. 1994, 9, 131–141.
- 91 Shah, S. A., Halloran, P. M., Ferris, C. A., Levine, B. A., Bourret, L. A., Goldmacher, V. S., Blattler, W. A., Anti-B4-blocked ricin irnmunotoxin shows therapeutic efficacy in four different SCID mouse tumour models. Cancer Res. 1993, 53, 1360–1367.
- 92 Gunther, R., Chelstrom, L. M., Finnegan, D., TuelAhlgren, L., Irvin, J. D., Myers, D. E., Uckun, F. M., In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein irnmunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency. Leukemia 1993, 7, 298–309.
- 93 Jansen, B., Vallera, D. A., Jaszcz, W. B., Nguyen, D., Kersey, J. H., Successful treatment of human acute T-cell leukaemia in SCID mice using the anti-CD7-deglycosylated ricin A chain immunotoxin DA7. Cancer Res. 1992, 52, 1314–1321.
- 94 Winkler, U., Gottstein, C, Schon, G., Kapp, U., Wolf, J., Hansmann, M. L., Bohlen, H., Thorpe, P., Diehl, V., Engert, A., Successful treatment of disseminated human Hodgkin's disease in SCID mice with deglycosylated ricin A-chain immunotoxins. Blood 1994, 83, 466–475.
- 95 Pasqualucci, L., Wasik, M., Teicher, B. A., Flenghi, L., Bolognesi, A., Stirpe, F., Polito, L., Falini, B., Kadin, M. E., Antitumour activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood 1995, 85, 2139–2146.
- 96 Jansen, B., Kersey, J. H., Jaszcz, W. B., Gunther, R., Nguyen, D. P., Chelstrom, L. M., Tuel-Ahlgren, L., Uckun, F. M. Effective immunochemotherapy of human t(4:11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (anti-CD 19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide. Leukemia 1993, 7, 290–297.
- 97 Ghetie, M. A., Tucker, K., Richardson, J., Uhr, J. W., Vitetta, E. S., Eradication of minimal disease in severe combined immunodeficient mice with disseminated Daudi lymphoma using chemotherapy and an immunotoxin cocktail. Blood 1994, 84, 702–707.
- 98 Honma, Y., Matsuo, Y., Hayashi, Y., Omura, S., Treatment of Philadelphia-chromosome- positive human leukemia in SCID mouse model with herbimycin A, bcr-abl tyrosine kinase activity inhibitor. Int. J. Cancer 1995, 60, 685–688.
- 99 Schwarz, M. A., Tardelli, L., Macosko, H. D., Sullivan, L. M., Narula, S. K., Fine, J. S., Interleukin 4 retards dissemination of a human B-cell lymphoma in severe combined immunodeficient mice. Cancer Res. 1995, 55, 3692–3696.
- 100 Schultz, L., Schweitzer, P. A., Christianson, S. W., Gott, B., Schweitzer, I. B., Tennent, B., McKenna, S., Mobraaten, L., Rajan, T. V., Greiner, D. L., Leiter, E. H., Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 1995, 154, 180–191.