Complex segregation analysis of families ascertained through Gilles de la Tourette syndrome
Corresponding Author
Susanne A. Seuchter
Institute of Medical Statistics, University of Bonn, Bonn, Germany
Institute of Medical Statistics, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany===Search for more papers by this authorJohannes Hebebrand
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Search for more papers by this authorBirgit Klug
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Search for more papers by this authorMichael Knapp
Institute of Medical Statistics, University of Bonn, Bonn, Germany
Search for more papers by this authorGerd Lehmkuhl
Department of Child and Adolescent Psychiatry, University of Köln, Köln, Germany
Search for more papers by this authorFritz Poustka
Department of Child and Adolescent Psychiatry, University of Frankfurt, Frankfurt, Germany
Search for more papers by this authorMartin Schmidt
Department of Child and Adolescent Psychiatry, University of Mannheim, Mannheim, Germany
Search for more papers by this authorHelmut Remschmidt
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Search for more papers by this authorMax P. Baur
Institute of Medical Statistics, University of Bonn, Bonn, Germany
Search for more papers by this authorCorresponding Author
Susanne A. Seuchter
Institute of Medical Statistics, University of Bonn, Bonn, Germany
Institute of Medical Statistics, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany===Search for more papers by this authorJohannes Hebebrand
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Search for more papers by this authorBirgit Klug
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Search for more papers by this authorMichael Knapp
Institute of Medical Statistics, University of Bonn, Bonn, Germany
Search for more papers by this authorGerd Lehmkuhl
Department of Child and Adolescent Psychiatry, University of Köln, Köln, Germany
Search for more papers by this authorFritz Poustka
Department of Child and Adolescent Psychiatry, University of Frankfurt, Frankfurt, Germany
Search for more papers by this authorMartin Schmidt
Department of Child and Adolescent Psychiatry, University of Mannheim, Mannheim, Germany
Search for more papers by this authorHelmut Remschmidt
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Search for more papers by this authorMax P. Baur
Institute of Medical Statistics, University of Bonn, Bonn, Germany
Search for more papers by this authorAbstract
Although family and twin studies suggest that genetic factors are involved in the etiology of Tourette syndrome and other related tic disorders, further evidence is needed to demonstrate that the familial transmission is consistent with known genetic factors. We performed a complex segregation analysis that allowed for a variable age of onset of Gilles de la Tourette, other tic disorders and obsessive compulsive phenotype information on 108 extended families, each ascertained through one Tourette proband by using regressive models that are able to incorporate additional explanatory variables and major gene effects. A special version of the S.A.G.E. program, REGTLhunt, was used to explore the likelihood surface of all examined models. Results indicated that the pattern of Tourette and other related tic disorders in our data sample is not consistent with Mendelian inheritance even after modelling explanatory variables such as obsessive compulsive symptomatology. Genet. Epidemiol. 18:33–47, 2000. © 2000 Wiley-Liss, Inc.
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