Volume 21, Issue 12 pp. 1790-1793
Short Report

Selective degeneration of sudomotor fibers in Ross syndrome and successful treatment of compensatory hyperhidrosis with botulinum toxin

Ilka Bergmann MD

Ilka Bergmann MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

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Michel Dauphin MD

Michel Dauphin MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

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Markus Naumann MD

Markus Naumann MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

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Peter Flachenecker MD

Peter Flachenecker MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

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Wolfgang Müllges MD

Wolfgang Müllges MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

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Martin Koltzenburg MD

Martin Koltzenburg MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

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Claudia Sommer MD

Corresponding Author

Claudia Sommer MD

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany

Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, GermanySearch for more papers by this author

Abstract

We report a 5-year follow-up of a patient with Ross syndrome. A biopsy of the anhidrotic skin immunostained with protein gene product 9.5 visualized by confocal microscopy revealed selective loss of sudomotor fibers, whereas epidermal innervation remained intact, providing the first morphologic evidence of selective loss of sudomotor fibers in this syndrome. Among the different treatment strategies employed for the patient's disabling segmental hyperhidrosis, intracutaneous injection of botulinum toxin A was the most helpful. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1790–1793, 1998

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