Selective degeneration of sudomotor fibers in Ross syndrome and successful treatment of compensatory hyperhidrosis with botulinum toxin
Ilka Bergmann MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorMichel Dauphin MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorMarkus Naumann MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorPeter Flachenecker MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorWolfgang Müllges MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorMartin Koltzenburg MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorCorresponding Author
Claudia Sommer MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, GermanySearch for more papers by this authorIlka Bergmann MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorMichel Dauphin MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorMarkus Naumann MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorPeter Flachenecker MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorWolfgang Müllges MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorMartin Koltzenburg MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Search for more papers by this authorCorresponding Author
Claudia Sommer MD
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
Neurologische Universitätsklinik, Josef-Schneider-Str. 11, 97080 Würzburg, GermanySearch for more papers by this authorAbstract
We report a 5-year follow-up of a patient with Ross syndrome. A biopsy of the anhidrotic skin immunostained with protein gene product 9.5 visualized by confocal microscopy revealed selective loss of sudomotor fibers, whereas epidermal innervation remained intact, providing the first morphologic evidence of selective loss of sudomotor fibers in this syndrome. Among the different treatment strategies employed for the patient's disabling segmental hyperhidrosis, intracutaneous injection of botulinum toxin A was the most helpful. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1790–1793, 1998
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