Ectopic impulse generation and autoexcitation in single myelinated afferent fibers in patients with peripheral neuropathy and positive sensory symptoms
Mario Campero MD
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Search for more papers by this authorJordi Serra MD
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Search for more papers by this authorPaolo Marchettini MD
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Search for more papers by this authorCorresponding Author
José L. Ochoa MD, PhD, DSc
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USASearch for more papers by this authorMario Campero MD
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Search for more papers by this authorJordi Serra MD
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Search for more papers by this authorPaolo Marchettini MD
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Search for more papers by this authorCorresponding Author
José L. Ochoa MD, PhD, DSc
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USA
Neuromuscular Unit, Good Samaritan Hospital & Medical Center and Oregon Health Sciences University, 1040 NW 22nd Ave., Suite 460, Portland, Oregon 97210, USASearch for more papers by this authorAbstract
Microneurographic studies were performed using cutaneous nerves of 8 patients with documented peripheral neuropathy who expressed positive sensory symptoms. Intraneural recordings in single myelinated fibers revealed: (i) ectopic generation of bursts of spontaneous action potentials; (ii) ectopic generation of ongoing repetitive discharges transiently interrupted by natural stimulation of the receptive field; and (iii) repetitive discharges triggered by a preceding action potential. These results provide direct evidence of a peripheral pathophysiological basis for spontaneous and stimulus-induced paresthesias and dysesthesias in patients with peripheral neuropathy. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1661–1667, 1998
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