Incidence of intracranial meningiomas in Nagasaki atomic-bomb survivors
Corresponding Author
Naoki Sadamori
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 12-4 Sakamoto 1-chome, Nagasaki 852, Japan. Fax: (81) 0958-49-7113Search for more papers by this authorShobu Shibata
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorMariko Mine
Department of Neurosurgery, Scientific Data Center for Atomic-Bomb Disaster, Nagasaki University School of Medicine, Nagasaki 852, Japan
Search for more papers by this authorHisaya Miyazaki
Department of Neurosurgery, Miyazaki Hospital, Isahaya 854, Japan
Search for more papers by this authorHitoshi Miyake
Department of Neurosurgery, Juzenkai Hospital, Nagasaki 850, Japan
Search for more papers by this authorMasaki Kurihara
Department of Neurosurgery, Juzenkai Hospital, Nagasaki 850, Japan
Search for more papers by this authorMasao Tomonaga
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorIchiro Sekine
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorYutaka Okumura
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorCorresponding Author
Naoki Sadamori
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, 12-4 Sakamoto 1-chome, Nagasaki 852, Japan. Fax: (81) 0958-49-7113Search for more papers by this authorShobu Shibata
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorMariko Mine
Department of Neurosurgery, Scientific Data Center for Atomic-Bomb Disaster, Nagasaki University School of Medicine, Nagasaki 852, Japan
Search for more papers by this authorHisaya Miyazaki
Department of Neurosurgery, Miyazaki Hospital, Isahaya 854, Japan
Search for more papers by this authorHitoshi Miyake
Department of Neurosurgery, Juzenkai Hospital, Nagasaki 850, Japan
Search for more papers by this authorMasaki Kurihara
Department of Neurosurgery, Juzenkai Hospital, Nagasaki 850, Japan
Search for more papers by this authorMasao Tomonaga
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorIchiro Sekine
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorYutaka Okumura
Departments of Internal Medicine, Pathology and Radiation Biophysics, Atomic-Disease Institute, Nagasaki 852, Japan
Search for more papers by this authorAbstract
Among the Nagasaki atomic-bomb survivors registered at the Scientific Data Center for Atomic-Bomb Disaster, Nagasaki University School of Medicine, 45 cases of surgically treated intracranial meningioma were collected from 6 hospitals with departments of neurosurgery in or near Nagasaki City during the period from 1973 to 1992. All 45 patients were over 40 years of age at the time of diagnosis. Subsequently, the 45 cases were statistically analyzed in relationship to the estimated distance from the hypocenter by age, gender, intracranial location, histology and latent period. The analysis showed a high correlation between incidence of meningiomas and distance from the hypocenter. The incidence among Nagasaki atomic-bomb survivors over 40 years of age, especially in those proximally exposed, appears to be increasing, in inverse proportion to the exposure distance, since 1981, 36 years after the explosion of the atomic bomb. © 1996 Wiley-Liss, Inc.
References
- Adamson, H. G., A simplified method of x-ray application for the cure of ringworm of the scalp: Keinböck's method. Lancet, 1, 1378–1380 (1909).
- Beller, A. J., Feinsod, M. and Sahar, A., The possible relationship between small-dose irradiation to the scalp and intracranial meningiomas. Neurochirurgia (Stuttg.), 15, 135–143 (1972).
- Bogdanowicz, W. M. and Sachs, E. Jr., The possible role of radiation in oncogenesis of meningioma. Surg. Neurol., 2, 379–383 (1974).
-
Cihak, R. W.,
Ishimaru, T.,
Steer, A. and
Yamada, A.,
Lung cancer at autopsy in A-bomb survivors and controls, Hiroshima and Nagasaki, 1961–1970. 1. Autopsy findings and relation of radiation.
Cancer,
33,
1580–1588
(1974).
10.1002/1097-0142(197406)33:6<1580::AID-CNCR2820330617>3.0.CO;2-R CAS PubMed Web of Science® Google Scholar
- Cochran, W. G., Some methods for strengthening the common X2 tests. Biometrics, 10, 417–441 (1954).
- Dimant, J. N., Loktinov, G. M. and Sataev, M. M., Induction of spinal-cord meningeal tumors in rabbits with radioactive cobalt. Vopr. Onkol., 11, 46–51 (1965).
- Harrison, M. J., Wolfe, D. E., Lau, T.-S., Mitnick, R. J. and Sachder, V. P., Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature. J. Neurosurg., 75, 564–574 (1991).
- Kishikawa, M. et al., Pathological study of brain tumors of the A-bomb survivors in Nagasaki. Hiroshima Igaku, 35, 428–430 (1982). (In Japanese).
-
Liu, P. I.,
Ishimaru, T.,
McGregor, D. H.,
Yamamoto, T. and
Steer, A.,
Autopsy study of leukemia in atomic-bomb survivors, Hiroshima-Nagasaki, 1949–1969.
Cancer,
31,
1315–1327
(1973).
10.1002/1097-0142(197306)31:6<1315::AID-CNCR2820310603>3.0.CO;2-C CAS PubMed Web of Science® Google Scholar
- Modan, B., Baidatz, D., Mart, H., Steinitz, R. and Levin, S. G., Radiation-induced head and neck tumors. Lancet, 1, 277–279 (1974).
- Munk, J., Peyser, E. and Gruszkiewicz, J., Radiation-induced intracranial meningiomas. Clin. Radiol., 20, 90–94 (1969).
- Nomura, K., WHO's new classification and brain-tumor statistics in Japan. Jap. J. Cancer Clin., 40, 1043–1052 (1994). (In Japanese).
- Parker, L. N., Belsky, J. L., Yamamoto, T., Kawamoto, S. and Keehn, R. J., Thyroid carcinoma after exposure to atomic radiation: a continuing survey of a fixed population, Hiroshima and Nagasaki, 1958–1971. Ann. Intern. Med., 80, 600–604 (1974).
- Ron, E., Modan, B., Boice, J. D., Alfandary, E., Stovall, M., Chetrit, A. and Katz, L., Tumors of the brain and nervous system after radiotherapy in childhood. New Engl. J. Med., 319, 1033–1039 (1988).
- Sadamori, N., Mine, M. and Hori, M., Skin cancer among atomic-bomb survivors. Lancet, 1, 1267 (1989).
- Sadamori, N., Otake, M. and Honda, T., Study of skin-cancer incidence in Nagasaki atomic-bomb survivors, 1958–85. RERF TR 10, 1–20 (1991).
- Schulz, R. J. and Albert, R. E., Follow-up study of patients treated by X-ray epilation for Tinea capitis. III. Dose to organs of the head from the X-ray treatment of Tinea capitis. Arch. Environ. Health, 17, 935–950 (1968).
- Shibata, S., Sadamori, N., Mine, M. and Sekine, I., Intracranial meningiomas among Nagasaki atomic-bomb survivors. Lancet, 344, 1770 (1994).
- Soffer, D., Pittaluga, S., Feiner, M. and Beller, A. J., Intracranial meningiomas following low-dose irradiation to the head. J. Neurosurg., 59, 1048–1053 (1983).
- Thompson, D. E., Mabuchi, K., Ron, E., Soda, M., Tokunaga, M., Ochikubo, S., Sugimoto, S., Ikeda, T., Terasaki, M., Izumi, S. and Preston, D. L., Cancer incidence in atomic-bomb survivors. Part II: Solid tumors, 1958–1987. Radiat. Res., 137, S17–S67 (1994).
- Wanebo, C. K., Johnson, K. G., Sato, K. and Thorslund, T. W., Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki. New Engl. J. Med., 279, 667–671 (1968).
- Yamamoto, T. and Kato, H., Two major histological types of gastric carcinoma among the fixed populations of Hiroshima and Nagasaki. Gann, 62, 381–387 (1971).
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