Volume 46, Issue 3 pp. 263-266

Research Article

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Investigation of the Mode of Action of Nematode Neuropeptides

Christopher D. Keating,

Christopher D. Keating

Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK

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Lindy M. Holden-Dye,

Lindy M. Holden-Dye

Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK

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Robert J. Walker,

Robert J. Walker

Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK

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Christopher D. Keating,

Christopher D. Keating

Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK

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Lindy M. Holden-Dye,

Lindy M. Holden-Dye

Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK

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Robert J. Walker,

Robert J. Walker

Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK

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First published: March 1996

https://doi.org/10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U

Citations: 4

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Abstract

The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, as did 100 μm theophylline in two out of six studies. The cyclic-AMP-potentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway.

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Volume46, Issue3

March 1996

Pages 263-266

Investigation of the Mode of Action of Nematode Neuropeptides

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Investigation of the Mode of Action of Nematode Neuropeptides

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