We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-I proviral DNA in the peripheral mononuclear cells by means of polymerase chain reaction. The phenotype of tumor cells revealed CD7+, CD5+, CD2+, CD3+, WT31−, TcR δ 1−, CD4−, CD8−, CD25−, and the karyotype showed a 5q-, t(12;18). HTLV-I unrelated ATL is very rare, and the karyotype as in our case has not been reported previously. Am. J. Hematol. 64:64–66, 2000. © 2000 Wiley-Liss, Inc.

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Volume64, Issue1

May 2000

Pages 64-66

HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype

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HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype

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